Tag: Technology advancement

A Comprehensive Technology Survey of Protein Microarray Platforms, Techniques and Detection Methods

A comprehensive assessment of multiplex immunoassay platforms and detection methods is summarized in an interesting 2011 article by Chandra, et al, in Expert Review Proteomics (1). The article, “Protein Microarrays and Novel Detection Platforms” provides interesting information for several reasons.First, it presents an excellent description of the emerging discovery and clinical need for high throughput … Continued

High Capacity Porous Nitrocellulose Microarray Substrates Enable Whole Proteome Serology Screening Assays for Antigenicity Profiling of Infectious Disease Agents

Insight into the dynamics of pathogenic infectivity has been greatly enhanced by studies using whole proteome microarray technology [1]. Techniques allowing high throughput production of recombinant proteins representing comprehensive antigenic potential of pathogenic bacteria and viruses allow examination of the degrees to which specific antigenic proteins are involved in human serological response.The true value of … Continued

View Your Proteins in 3-D!

Protein microarray technology has progressed significantly and, although new microarray surface chemistries continue to be developed and marketed, porous nitrocellulose has remained the predominant immobilization surface for protein microarray applications due to its many functional advantages.  The 3-dimensional structure of nitrocellulose film slides offers a considerably higher surface area for protein binding compared to conventional … Continued