Proteomics is a powerful approach to understanding what role proteins play in disease development, growth, treatment, and recovery. Most proteome research is focused on analyzing plasma and serum, as well as studying cell signaling pathways in cancer. However, saliva and urine matrices are gaining attraction due to the relatively simple, non-invasive collection method that can … Continued
Antigen Discovery Inc.’s protein microarrays allow for highly multiplexed assays the generate hundreds, thousands and tens of thousands data points for each sample tested. Antigen Discovery Inc., our collaborators and our customers have leveraged this technology to peer into the complex intricacies of the immune response to disease generating over 80 peer-reviewed research articles in … Continued
Studies of biological systems have expanded beyond the ‘one gene, one protein’ paradigm to the field of proteomics, or studying large numbers of proteins that act in a concert of complex biological systems. Thus in the post-genome era, technology has been driven to deliver multiplex assays that allow us to monitor multiple proteins in parallel, … Continued
Michael A. Shultz, Aki Ohdera, Jason MacManiman, Charles M. McGrath. Grace Bio-Labs, Inc. ABSTRACT Super G Blocking Buffer was developed to produce low backgrounds in assays using nitrocellulose film-slides. Using this blocking reagent in combination with ONCYTE® SuperNOVA Film-slides, we achieved an order of magnitude greater sensitivity in a cytokine microarray assay than with … Continued
A recent article (1) reporting on a conference in Edinburgh, Scotland, discusses the progress in ‘affinity proteomics’, that is, antibody-based assays including protein microarrays and their potential for use in clinical diagnostics. There continues to be much optimism around the use of antibody-based microarrays for diagnostics, and yetthe emergence of this technology has been slower than … Continued
Microarray technology was first exploited with genomic analysis of DNA sequences. This technology still forms a robust platform for biomarker discovery and comparative genomics. However, while genomics sheds light on the biological potential, a recent review in Science Signaling points out that “protein does the heavy lifting in the cell, and neither DNA nor RNA says much … Continued