Tag: P. falciparum

RPPA Reveals Altered Phosphorylation Profile in Plasmodium-infected Hepatocytes

Introduction Plasmodium parasites inflict widespread global disease, which in the case of malaria is caused by the intraerythrocytic form of the parasite.  The parasite infects the host by traveling to the liver where it intracellularly develops and affects hepatocyte cells, initiating a range of responses including autophagy and apoptosis.  Different hosts, and even different hepatocyte … Continued

Targeted Malarial Serological Diagnostics using ONCYTE Porous Nitrocellulose Film Microarray

Targeted diagnostic serological screening using ONCYTE porous nitrocellulose (PNC) microarrays is currently greatly expanding. Interesting research in the Felgner laboratory at UC Irvine has centered on identifying and monitoring P. falciparum antigens involved in malaria infection using subsets of its viral proteome produced via a recombinant expression system and arraying on PNC. Recently, in collaboration … Continued