Epitope mapping allows the identification of polyclonal antibodies produced as a response to cytotoxins, allergens, neuronal or inflammatory conditions and, in autoimmune diseases to autoantigens. Routine assays for autoimmune response profiling are generally performed by ELISAs and fluorescence immunoassays. Individual assays are performed in microtiter plates, with each well representing a single antigen. Peptide microarrays provide … Continued
The hallmark of chronic diseases is the production of highly specific autoantibodies (1,2). These autoantibodies are increasingly measured to guide clinical decision making. The goal of these measurements is to define intracellular signal pathway activation profiles. These profiles can be integrated with clinical information to generate “biosignatures” for individual patients, the goal of which is personalized … Continued
We are pleased to present a recent talk by Grace Bio-Labs Scientist Kevin Carman. Summary: U1 snRNP and Smith antigen auto-antibodies are important markers in several autoimmune disorders. Auto-antibodies against these extractable nuclear antigens (ENA’s) are commonly used as clinical diagnostic criteria for Sjorgen’s Syndrome, SLE, and MCTD.
Antigen Discovery Inc.’s protein microarrays allow for highly multiplexed assays the generate hundreds, thousands and tens of thousands data points for each sample tested. Antigen Discovery Inc., our collaborators and our customers have leveraged this technology to peer into the complex intricacies of the immune response to disease generating over 80 peer-reviewed research articles in … Continued