Protein crystallization is a key assay for structural studies of proteins. The protocols for crystallization of protein are challenging due to the stringent requirement for pure samples and control of environmental conditions during the crystallization process. Vapor diffusion using hanging drop is a preferred method for obtaining quality crystals with…
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Grace Bio-Labs microarray surface chemistry is based on the well-known protein-binding properties of nitrocellulose. A range of different formulations have…
Antigen-Capture Assay; Antibody Capture Assay; Coronavirus Antigen Array; Epitope-mapping; Biomarker Discovery and Validation; Immunogen Discovery;
Epoxy Microarray Slides provide a uniform substrate for a variety of DNA/RNA-based diagnostic applications.
DNA/Oligonucleotide Microarray ; microRNA Microarray ; Single Nucleotide Polymorphism (SNP) Analysis ; Gene Expression Profiling;
Grace Bio-Labs microarray regents have been specifically formulated to achieve the full potential of porous nitrocellulose, accelerating experimental design and…
Antigen-Capture Assay ; Antibody Capture Assay; RPPA- Reverse Phase Protein ; Microarray Laser micro-dissection; RRPA Epitope-mapping ; Biomarker Discovery and Validation; Immunogen Discovery;
Photostable nanoparticles arrayed on glass slides for calibration of fluorescence imaging systems and quantitative analysis.
Calibration of Microarray Scanners ; Quantitative Microarray Analyses Microscope Focal Plane Adjustment; Microscope Focal Plane Adjustment;
ProPlate® re-usable, multi-well chambers are available in a wide variety of formats to fit standard 1 x 25 x 75…
Microarray ; Hybridization and Incubation; ELISA; PCR and NGS;
CoverWell™ incubation chambers are reusable, easy to apply chambers that attach without the use of adhesive. CoverWells™ enclose a large…
Reverse Transfection Microarray; DNA Microarray; In-situ hybridization; Immunohistochemistry;
Silicone Isolators allow researchers to isolate specimens using removable hydrophobic barriers. They may be used to isolate cells grown in…
SecureSeal™ Hybridization Chambers are thin, silicone-gasketed chambers providing optimal surface-to-volume fluid dynamics for hybridization assays on large or multiple specimens…
HybriWell™ Sealing System bonds securely to a microscope slide surface in seconds to confine small reagent volumes with samples and…
Hybridization and incubation Seals ad Chambers from Grace Bio-Labs are ideally suited for in situ-hybridization assays. The adhesive seal of…
In-situ hybridization ; Microarrays; Fluorescence In situ Hybridization (FISH); FRET (Fluorescence Resonance Energy Transfer);
FastWells™ are sticky, flexible silicone gaskets that form hydrophobic reagent barriers around specimens without messy adhesives or special slides. Gaskets may…
FlexWell™ incubation chamber silicone gaskets form wells on slides using clean release adhesive to isolate up to 16 specimens per…
HybriSlips™ are rigid, light-weight, thin plastic coverslips that minimize friction and facilitate uniform reagent distribution during incubation steps which require…
ProPlates® were specifically designed to enable automated robotic liquid handling. Two main configurations are available: The ProPlate® Microtiter Plate is comprised…
Proteomics; Protein Microarrays; Protein expression analysis; Antibody profiling ; cDNA and oligonucleotide arrays;
Silicone isolator™ sheet material allows researchers to create their own removable hydrophobic barriers to isolate specimens. Where additional sealing is…
Protein and DNA arrays ; Immunohistochemistry; Fluorescence In situ Hybridization (FISH) ; Biopolymers and hydrogel formulation ; Cryogenic-transmission electron microscopy (Cryo-TEM) ; Microwave crystallization ; Ultra-small-angle X-ray scattering (USAXS) ; Tissue ingeneering; Live cell lithography” (LCL);
Grace Bio-Labs microscopy reagents are manufactured in ISO-certified facilities to ensure the highest quality and consistency.
Imaging spacers are ultra-thin adhesive spacers which peel-and-stick to coverglass or microscope slides to confine specimens without compression. Layer multiple…
Imaging; Microscopy; High-temperature single-molecule kinetic analysis; Anti‐Stokes Raman scattering microscopy;
CoverWell ™ imaging chambers are designed to stabilize and support thick and free-floating specimens for confocal microscopy and imaging applications.…
Confocal microscopy ; Imaging ; Tissue and Cell staining ; High Resolution Microscopy ; Live-cell imaging ;
CoverWell ™ perfusion press-to-seal covers form water-tight, multiwell cell incubation or cytochemistry chambers when pressed to coverslips or microscope slides.…
Single molecule spectroscopy ; Live-cell imaging ; Microscoscopy ;
FastWells™ are sticky, flexible silicone gaskets that form hydrophobic reagent barriers around specimens without messy adhesives or special slides. Gaskets may…
Microscopy ; Fluorescence In situ Hybridization (FISH) ; Single-molecule fluorescence analysis ; Immunohistochemistry ;
MutliSlip™ inserts with 8 (18mm x 18mm) or 15 (12mm x 12mm) No. 1.5 German glass coverglass per insert are…
High resolution microscopy; Fluorescent imaging; Immunohistochemistry ; Cell Culture;
These adhesive sheets are made using the same SecureSeal™ adhesive as is used to make HybriWell™ and SecureSeal™ Incubation Chambers. Thin,…
Imaging ; Tissue and Cell staining ; High Resolution Microscopy;
SecureSlip™ Silicone Supported Coverglass is affixed to a thin microscopically transparent silicone base which secures it to culture vessels by…
Imaging seals and chambers from Grace Bio-Labs offer a selection of tools for cell/tissue staining for high quality results in…
Tissue and Cell staining; High Resolution Microscopy; Live-cell imaging;
Grace Bio-Labs microscopy reagents are manufactured in ISO-certified facilities to ensure the highest quality and consistency.
CultureWell- removable chamber slide allows the cultivation and analysis of cells directly on a borosilicate microscope slide.
Fluorescence microscopy ; Confocal microscopy ; Cell differentiation and transfection; Immunohistochemistry ; Immunofluorescence; Immunostaining; Tissue and cell staining ; Fluorescence Resonance Energy Transfer (FRET) Microscopy;
CultureWell™ chambered coverglass products consist of removable and reusable, non-cytotoxic silicone gaskets secured to number 1.5 German coverglass. Chambered coverglass…
Cell Culture ; Fluorescence applications ; In-situ hybridization ; Immunostaining ;
CS16 CultureWell™ removable chambered coverglass is a 16-well chambered coverglass cell culture vessel, with 2 x 8 format with standard…
Cell Culture; Fluorescence applications; In-situ hybridization; Immunostaining ;
Each CultureWell™ coverglass insert is comprised of four chambered coverglass, assembled in a disposable frame placed in a standard 86mm…
High resolution microscopy ; Fluorescent imaging ; Immunohistochemistry;
Gaskets are ideal for forming wells on glass microscope slides or in polystyrene dishes. Gaskets are non-sterile and may be…
Cell Culture; High resolution microscopy; Fluorescent imaging ; Immunohistochemistry;
CultureWell™ clear silicone sheet material allows researchers to create their own removable hydrophobic barriers to isolate specimens. They may be…
Cell Culture; High resolution microscopy ; Fluorescent imaging; Immunohistochemistry;
MutliSlip™ inserts with 8 (18mm x 18mm) or 15 (12mm x 12mm) No. 1.5 German glass coverglass per insert are…
SecureSlip™ Silicone Supported Coverglass is affixed to a thin microscopically transparent silicone base which secures it to culture vessels by…
CultureWell™ NON Removable Chambered Coverglass, 16 Well, No. 1.5 German borosilicate Coverglass. Product consists of cell culture vessels, with a…
Cell Culture ; Fluorescence applications; Small volume incubation ; Immunostaining;
Wound splints are constructed of silicone and include suture sites for increased precision in affixing on or within an animal…
Silicone isolator™ sheet material allows researchers to create their own removable hydrophobic barriers to isolate specimens. Where additional sealing is…
Protein and DNA arrays ; Immunohistochemistry ; Fluorescence In-situ Hybridization (FISH) ; Biopolymers and hydrogel formulation; Cryogenic-transmission electron microscopy (Cryo-TEM) ; X-ray scattering ; Microwave crystallization ; Ultra-small-angle X-ray scattering (USAXS) ; Tissue engineering Live cell lithography (LCL);
CultureWell™ clear silicone sheet material allows researchers to create their own removable hydrophobic barriers to isolate specimens. They may be…
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SARS-CoV2 seroprevalence data indicates that asymptomatic transmission is largely underreported. It is also known to play an important role in disease transmission among the general population. Asymptomatic individuals, defined as persons with no clinical symptoms, no radiological sign of the disease in the lungs, and a positive SARS-CoV2 nucleic acid test result, shed viral particles … Continued
Protein glycosylation is a complex post-translational modification (PTM) that provides great proteomic diversity. It involves the attachment of sugars at specific amino acid residues. Asn (N-linked) or Ser/Thr (O-linked) being the residues most frequently glycosylated. Glycosylation is critical for physiological and pathological cellular functions and affects the bioavailability, efficacy, stability, and solubility of therapeutic glycoproteins. … Continued
Convalescent plasma is a potential therapeutic option for patients with coronavirus disease. The therapy is based on the administration of plasma containing antibodies against SARS-CoV-2 to help patients boost their responses to the coronavirus. Additionally, convalescent plasma can also be used for passive immunization with the potential to prevent viral infection. In both applications, determining … Continued
Emerging studies in the field of glycobiology are beginning to reveal a complex and diverse realm of critical and abundant sugar-based polymers that support a wide range of biological processes. Glycans cannot be studied by molecular weight alone and they have an exceptionally diverse range of structures and functions, making them difficult to study. The US … Continued
Protein glycosylation analysis presents some inherent challenges due to the complexity of glycans. Determination of the mass, linkage, Isomerization and anomerization state of a protein require a combination of approaches for which relatively large amounts of proteins are needed. Such amounts are not always available when analyzing precious clinical specimens, making it difficult to extend … Continued
The analysis of antibody interactions to 19,500 recombinant full-length human proteins featured on HuProt™ Human Proteome Microarray provides a robust and rapid method to evaluate antibodies’ quality. Introduction Antibodies are the most commonly used research tools. Applied in basic research as well as in clinical and diagnostic medicine, their quality, consistency, and availability are fundamental … Continued
Epitope mapping allows the identification of polyclonal antibodies produced as a response to cytotoxins, allergens, neuronal or inflammatory conditions and, in autoimmune diseases to autoantigens. Routine assays for autoimmune response profiling are generally performed by ELISAs and fluorescence immunoassays. Individual assays are performed in microtiter plates, with each well representing a single antigen. Peptide microarrays provide … Continued
Reverse phase protein arrays (RPPA) offer great promise for the identification and use of critical biomarkers for drug screening and diagnostics. Samples prepared from tissue lysate that are spotted for RPPA can often produce dilute protein concentrations, sometimes only a few hundred µg/ml. For single spot depositions in an array, this utilizes less than 1% of … Continued
