SARS-CoV2 seroprevalence data indicates that asymptomatic transmission is largely underreported. It is also known to play an important role in disease transmission among the general population. Asymptomatic individuals, defined as persons with no clinical symptoms, no radiological sign of the disease in the lungs, and a positive SARS-CoV2 nucleic acid test result, shed viral particles … Continued
Author: Daniel Swain
RNA sequential probing of targets (SPOTs) is a newly developed method for mRNAs profiling, based on sequential Fluorescence In Situ Hybridization (seqFISH). SeqFISH is a technology that enables the identification of many RNA transcripts directly in single cells preserving spatial context. To demonstrate the method “mRNA, extracted from mouse cells, was captured on a locked nucleic acid … Continued
HybriWell™ hybridization chambers are the ideal tool for conserving precious or costly reagents in imaging experiments. HybriWells™ are inexpensive, disposable devices that create a chamber whose ports allow liquid exchange via microfluidic passive pumping , as demonstrated in this video: Seitz et, al. recently applied the method to develop and test fluorescence-based genetically-encoded biosensors to study … Continued
Protein glycosylation is a complex post-translational modification (PTM) that provides great proteomic diversity. It involves the attachment of sugars at specific amino acid residues. Asn (N-linked) or Ser/Thr (O-linked) being the residues most frequently glycosylated. Glycosylation is critical for physiological and pathological cellular functions and affects the bioavailability, efficacy, stability, and solubility of therapeutic glycoproteins. … Continued
Surface-enhanced Raman spectroscopy (SERS) technology is increasingly being adopted in biomedical analysis and imaging. A group of researchers at the University of Padova, Italy recently adopted the technology to capture and analyze tumor cells in peripheral blood. Cancer cells released from the primary tumor into the lymphatic system or in the bloodstream have the potential … Continued
Scientists at Tufts University and Harvard Medical School have developed a method to cryopreserve infectious Cryptosporidium oocysts. The results were published in Scientific Reports. Cryptosporidium is a microscopic parasite that causes the diarrheal disease cryptosporidiosis. While this parasite can be spread in many different ways water is the main source of transmission. Infants and immunocompromised adults are most at … Continued
Humoral immune response profiling is a valuable tool for the identification of potential targets for vaccine development. Immunogenicity studies in clinical trials are usually performed by ELISA assay. However, technical constraints limit the number of antigens that can be simultaneously analyzed. These limitations can be overcome by employing microarray technology, where antigenic reactivity can be … Continued
Human-induced pluripotent stem cell (iPSC) technology has taken the center stage in regenerative medicine research thanks to its enormous potential for personalized treatment and drug screening applications. Reprogramming somatic cells to generate iPSCs (induced pluripotent stem cells) is not only an easier and faster way to obtain stem cells, but is also devoid of the ethical … Continued
It is always fascinating to learn how our customers take advantage of the versatility of Grace Bio-Labs’ ProPlate® Multi-Well Chambers. Initially designed to take full advantage of the multiplexing and high-throughput potential of microarray technology, ProPlates feature a compressible gasket applied on a polycarbonate upper chamber. Affixed on a glass slide they create the leak-proof … Continued
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Convalescent plasma is a potential therapeutic option for patients with coronavirus disease. The therapy is based on the administration of plasma containing antibodies against SARS-CoV-2 to help patients boost their responses to the coronavirus. Additionally, convalescent plasma can also be used for passive immunization with the potential to prevent viral infection. In both applications, determining … Continued